When we will get Vaccinated?

 

Vaccines typically require years of research and testing before reaching the clinic, but scientists are racing to supply a secure and effective corona-virus vaccine by next year. Researchers are testing 55 vaccines in clinical trials on humans, and a minimum of 87 preclinical vaccines are under active investigation in animals.

PRECLINICAL TESTING: Scientists test a replacement vaccine on cells then provides it to animals like mice or monkeys to ascertain if it produces an immune reaction . we've confirmed 87 preclinical vaccines in active development.

PHASE 1 SAFETY TRIALS: Scientists give the vaccine to a little number of individuals to check safety and dosage also on confirm that it stimulates the system .

PHASE 2 EXPANDED TRIALS: Scientists give the vaccine to many people split into groups, like children and therefore the elderly, to ascertain if the vaccine acts differently in them. These trials further test the vaccine’s safety and skill to stimulate the system .

PHASE 3 EFFICACY TRIALS: Scientists give the vaccine to thousands of individuals and wait to ascertain what percentage become infected, compared with volunteers who received a placebo. These trials can determine if the vaccine protects against the corona-virus. In June, the F.D.A. advised vaccine makers that they might want to ascertain evidence that vaccines can protect a minimum of 50 percent of these who receive it. additionally , Phase 3 trials are large enough to reveal evidence of relatively rare side effects which may be missed in earlier studies.

EARLY OR LIMITED APPROVAL: China and Russia have approved vaccines without expecting the results of Phase 3 trials. Experts say the rushed process has serious risks.

APPROVAL: Regulators in each country review the trial results and choose whether to approve the vaccine or not. During an epidemic , a vaccine may receive emergency use authorization before getting formal approval. Once a vaccine is licensed, researchers still monitor people that receive it to form sure it’s safe and effective.

COMBINED PHASES: a method to accelerate vaccine development is to mix phases. Some coronavirus vaccines are now in Phase 1/2 trials, for instance , during which they're tested for the primary time on many people. (Note that our tracker counts a combined Phase 1/2 trial as both Phase 1 and Phase 2.)

Moderna develops vaccines based on messenger RNA (mRNA) to produce viral proteins in the body. They have yet to bring one to the market. In January, they began developing a vaccine for the corona-virus. The vaccine contains genetic instructions for building a coronavirus protein, known as spike. When injected into cells, the vaccine causes them to make spike proteins, which then get released into the body and provoke a response from the immune system.

The United States government bankrolled Moderna’s efforts, providing nearly $1 billion in support. In partnership with National Institutes of Health, they found that the vaccine protects monkeys from the coronavirus. In March, the scientists were the first to put a Covid-19 vaccine into human trials. After those studies yielded promising results, Phase 3 testing on 30,000 volunteers began on July 27.

On Nov. 16, Moderna announced that a preliminary analysis of the trial indicated that the vaccine was 94.5 percent effective. Out of 95 participants who got Covid-19, 90 had the placebo and only 5 had the vaccine. The results came just a week after Pfizer made a similar announcement about their own vaccine, which is also based on an mRNA molecule encoding the spike protein. Another promising result from Moderna’s trial was the finding that the vaccine appears to protect people from severe disease. Of the 11 volunteers who developed severe disease, none were vaccinated. The trial will continue to gather more results; Moderna says it plans to submit an application for an emergency use authorization in the next few weeks.

On the business side, Moderna lost a patent dispute in July over some of their vaccine technology. The following month, the company stated that it could not be certain it was the first to make the inventions claimed in their patents, including its coronavirus vaccine. Meanwhile, the company has entered deals with several countries to supply the vaccine if it’s approved. On Aug. 11, the United States government awarded the company an additional $1.5 billion in exchange for 100 million doses if the vaccine proves safe and effective. Moderna has made similar deals with Canada, Japan, and Qatar.

 

Pfizer, which developed the vaccine with its partner BioNTech, said the companies planned to apply to the Food and Drug Administration for emergency authorization “within days,” raising hopes that a working vaccine could soon become a reality.

The drug maker Pfizer said on Wednesday that its coronavirus vaccine was 95 percent effective and had no serious side effects — the first set of complete results from a late-stage vaccine trial as Covid-19 cases skyrocket around the globe.

The data showed that the vaccine prevented mild and severe forms of Covid-19, the company said. And it was 94 percent effective in older adults, who are more vulnerable to developing severe Covid-19 and who do not respond strongly to some types of vaccines. If the F.D.A. authorizes the two-dose vaccine, Pfizer has said that it could have up to 50 million doses available by the end of the year, and up to 1.3 billion by the end of next year.

 However, only about half of its supply will go to the United States this year, or enough for about 12.5 million people — a sliver of the American population of 330 million. Americans will receive the vaccine for free, under a $1.95 billion deal the federal government reached with Pfizer for 100 million doses.

 The companies said that out of 170 cases of Covid-19, 162 were in the placebo group, and eight were in the vaccine group. Out of 10 cases of severe Covid-19, nine had received a placebo.

Pfizer and BioNTech said that the vaccine’s efficacy was consistent across age, race and ethnicity. The most common serious adverse event was fatigue, with 3.7 percent of volunteers reporting tiredness after they took the second dose. Two percent of volunteers reported a headache after the second dose. Older adults reported fewer and milder side effects, the companies said.

“It’s pretty amazing,” said Akiko Iwasaki, an immunologist at Yale University. She said the results in people over 65 were the most promising. “We know from the influenza vaccine that it’s very difficult to achieve protection in this age group with vaccines,” she said, so 94 percent efficacy in that group “is really remarkable.”

Federal health officials have said the first doses of the vaccines will most likely go to groups like health care workers who are at high risk for exposure, as well as to people who are most vulnerable to the disease, such as older people.

 Note: But one of the biggest problems in these two vaccines is that they can be stored only in deep freeze. Whose temperature is minus 70 degrees Celsius. 

Pfizer's covid-19 vaccine "distribution will be a logistical nightmare." Cold chain logistics will be big challenge in vaccinating 135 crore Indians. We have certain smaller cold rooms that can store a million dose at 40 degrees also but not in a huge volume so probably in a month 2 million dose can be handled at 30 to 40 degrees according to Indian government.

Ramping up cold storage facilities critical as India preparations for covid-19 vaccine expert airline and airports get ready for operation covid vaccine.

Side effects of vaccine

• Moderna reported more grade 3 side effects. There was fatigue in 9.7 % of recipients, muscle pain in 8.9% joint pain in 5.2 % headache in 4.5 % pain in 4.1% and redness at the injection on-site in 2%.

• Pfizer reported 3.8 % of the recipient felt fatigue and 2% experienced headache, based on preliminary data from its phase 3 trials.

• No other major side effects until now, will continue monitoring said doctors. Doctors also said that the side effects of the vaccine can be seen even in 6 months.

Who will get the vaccine first?

• Covid-19- 30000000 frontline workers to be vaccinated 1st says health ministry.

• According to Modi government has set aside Rs 50,000 crore to give covid vaccine to entire country.

• On 11 August 2020 Russia approves first coronavirus vaccine 'Putin' says his daughter received dose.

• The announcement of the 'Sputnik V' vaccine for covid-19 was made by Russia. However, the vaccine is yet to complete final result.

When everything will be back to the normal?

• Drug makers push forward on large scale production of coronavirus vaccine which is called at risk manufacturing we don't know if our vaccine will work or not but if done we will get the license for further manufacturing.

• Pfizer and Moderna covid vaccine could be ready for US use in weeks.

• India to get covid-19 vaccine by med 2021 says BIOCON's Kiran Mazumdar say. Common people have to wait till 2022 to to get covid-19 vaccine AIIMS director Dr Randeep Guleria said.
  

 

Has India passed the covid-19 peaks? Can we remove our masks now? 

Finally some good news India’s covid cases numbers are reducing every day in September we saw daily covid cases of almost 1 lakh. But for the last consecutive 8 days the covid cases are less than 50000 so can we finally take of our masks?

Well it's not that simple it depends on the further outlook is good or bad.

Is India emerging now from Covid-19?

1. Cases in India are decreasing but the situation is opposite in worldwide.

• England has declared a second lockdown till December.

• England they had controlled the spread cases were following curve was flattering. In June, there were no cases, but suddenly more than two thousand cases are being found.

• and this is not the case and only one European country.

• Israel, Germany, France and Italy are saying second waves.

When you sneeze, cough or even talk, you release droplets these fluids settle on surface which can help the virus spread. 

According to experts droplets evaporate in summers and the virus doesn't spread as much but during winters the transmission of virus spread faster with the help of contact transmission & aerosol transmission.

Droplets will take longer to evaporates in the winters this will increase the rate of droplet transmission all of us have to be extra careful in winters.

2. How reliable are these low positive daily numbers.

• There are two types of Covid tests conducted in India.

1. One is the RT-PCR Test and

2. And second is the Rapid Antigent Test.

• RT-PCR Test is slow to give result but is more accurate. Rapid Antigen Test give fast result but give false negative too.

• Not all states are transparent about which test are happening. The Sero-survey further revealed that for every confirmed covid-19 cases in May there were 82.130 infections that went undefeated.

• we don't really know how many people are infected but haven't been captured in contact tracing or testing.

• We however have to admit our mortality rate is lesser than other countries and that is good news.

• However our country's population is 138 crore and only 11 crore covid test has been conducted in our country this means less than 10% of our population has been tested and that's bad news.

3. Is our fight against covid or against death?

• India has the most covid recoveries worldwide. There is a huge risk between the positive news.

• Due to covid some patients who survive covid-19 may suffer lasting lung damage.

• Please read the experiences of covid patients online and listen to doctors interviews they all mentioned about the long-term impacts of covid-19.

• Research by David Cox, science news says everyone out of three covid patients can have severe lung damage and air pollution can be fatal for such patients.

• 17 % covid deaths linked to pollution. Air pollution can put every one out of five patients in critical condition maybe these deaths may not get counted as covid deaths but thinking a little bit about their life is our responsibility.

• Rajasthan and Orissa ban crackers for safety of covid patients we need to take such decisions to reduce air pollution in India. It feels very good when people in the society came together understand the circumstances and take this decision together. We need to control air pollution at our individual level we owe it to those 7600000 people who are at risk.

• This time we are all ready to unite to celebrate Diwali but remember that if you burn firecrackers or create any kind of air pollution in this Diwali, then it will be very dangerous for the patient who has just emerged from Covid or for those who are still battling against covid. According to doctors and research, this time if any covid patient came in contact of any kind of air pollution, then they may have to face very long lung damage.

Ultimately, are these chances of a second wave in India?

This is paradox, if more people think we have defeated covid no second wave will come then we will have a second wave of infections for sure because we will stop taking precautions and if more people believe that a second wave will come then they take as many precautions as they did in May. Then maybe, we can control the second wave of infections.

We're 8 months into the covid-19 pandemic but we still haven't learned how to wear a mask properly please correct those people who wear the mask in these ways.

Cases are reducing but it doesn’t mean we become overconfident and stop taking any precautions at all. Yes, today India’s covid numbers are reducing and this news will really be good news for India When numbers flatline even after the winter/festive season.

Till the time we don't have a vaccine and it reaches everyone we haven’t won the fight against the covid-19.

But news over here is that you get to decide India's future because wearing a mask is in your hands, reducing air pollution is in your hands, and cooperating and not being a covid-idiot is in your clean hands.

 Arnab Goswami Arrested, Sent To Judicial Custody For 2 Weeks

"Arnab Goswami arrested"

• While Anvay was the director of Mumbai-based architectural and interior designing firm Concorde Designs, his mother Kumud, who was also found dead within the bungalow along side him, was on the board of directors of the firm.

• For the daughter and wife of Anvay Naik, who died by suicide in May 2018 at their Alibaug bungalow along with his mother, the arrest of three persons whom he had named within the suicide note, including Republic TV editor-in-chief Arnab Goswami, “is the primary step within the battle for justice” that has been ongoing for 2 years.

• Adnya Naik, Anvay’s daughter, told The Indian Express on Wednesday, “Goswami has been doing shows about the suicide of Sushant Singh Rajput and aggressively seeking arrests albeit no suicide note was left behind. In the case of my father and grandmother, they left behind a suicide note specifically naming Goswami and two others but no action was taken against them for nearly two years.”

• While Anvay was the director of Mumbai-based architectural and interior designing firm Concorde Designs, his mother Kumud, who was also found dead within the bungalow along side him, was on the board of directors of the firm.

• In a suicide note left behind by Anvay, he had said that he and his mother were taking the extreme step on account of payments due to them from three persons — Goswami of Republic TV, Feroz Shaikh of IcastX/Skimedia and Niteish Sarda of Smartworks. All three were arrested on Wednesday.

• Adnya and her mother Akshata said they need done everything from starting a YouTube channel, writing to the Prime Minister’ Office to approaching Goswami himself, so as to urge justice.

• “Right from the day of the suicide, there has been pressure on us to not get an FIR lodged. The police then told us that powerful people were involved and that we shouldn't get an FIR registered. However, once we insisted, an FIR was registered,” Adnya said.

• Also an interior designer, Adnya alleged that around January last year, her mother and she met investigating officer Suresh Varade in the Alibaug traffic police station. “He spoke to us nicely and asked us to sign a press release that said we we wanted to require the complaint back. We were shocked. When we tried taking a photograph of the statement, he pushed us and tore it,” she said.

• “We spoke to Raigad SP Anil Paraskar about it subsequent day but he didn't do anything. Whenever we met him, he kept saying the investigation is on.”

• A departmental inquiry has been ordered by the IG (Konkan Range) against Varade, currently posted as the senior inspector at Virar police station, for “wilfully omitting facts” during investigation. When contacted, Varde said, “I don't want to comment. I will face the inquiry.”

• While Paraskar also refused to comment, an officer said the family had complained to the SP about the incident. “Varade had then said that he was just notifying the family that a closure report was being filed,” a senior officer said.

• Adnya alleged that the worst part was that they were not even aware of the Raigad police filing a closure report in the case for want of evidence. “It was only during a statement issued by Republic TV this year that we came to understand that the case has been closed. We then asked our lawyers to get the necessary paperwork. Earlier, it had taken us eight months to get the suicide note.”

• She added that they also faced threats, especially after her mother started posting videos online. “We had filed four non-cognizable complaints — two each with Dadar and Murbad police. After uploading videos on social media, we received threatening phone calls… In Murbad, a bike-borne person told me that he knew where we were staying,” said Adnya.

• Following the four complaints, the police had issued a notice to Goswami to sign a bond of excellent behaviour. On allegations of Goswami being arrested due to political vendetta, Akshata said, “This is justice for a family that had been fighting against powerful people like Goswami. Only people who do not know about our struggle can make such statements.” “What has happened to us has not happened to the families of the politicians alleging political vendetta,” Adnya added.

• “We do not want to make this political. It is about a family seeking justice for two of its members. Even now, when we see the emails written by my father to Arnab asking him to return dues of Rs 83 lakh, we start crying. He had mailed him a couple of times the month before his suicide and called it ‘a matter of life and death’ in the mail, but there was no response,” Adnya said.

• Republic TV said it has already settled nearly 90 per cent of the dues.“Despite multiple emails, messages to Mrs Akshata Naik and Ms Adnya Naik regarding willingness to make sure a full and final settlement, no concrete response has been received. Mrs Akshata Naik demanded within the past that each one payments thanks to Concorde be made to 3rd party vendors but ARG is contractually obligated to form all payments to CDPL and not third parties.”